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¡buıɥʇʎuɐ ǝɯ ʞsɐ!   pretty pictures of research chemicals et al psychedelia.

Lol. What is this sign for and why is it in front of a funeral home?

Lol. What is this sign for and why is it in front of a funeral home?

— 18 hours ago with 4 notes
4 20mg caps of 4-ho-met a blunt and a book on basic neurochemistry.

4 20mg caps of 4-ho-met a blunt and a book on basic neurochemistry.

— 1 day ago with 20 notes
polydruguse asked: Hey, in order to really determine whether psilacetin is active in the brain or not, couldn't one just ingest 4-AcO-DMT together with some deacetylase inhibitor? Also, people say the effects differ from psilocin, but could it just be that some of the other alkaloids in mushrooms contribute to this distinction? I'd like to see someone try pure 4-HO-DMT and compare with 4-AcO-DMT.


Answer:

This sounds like a good idea if your proposed mechanism of action is correct. Keep in mind: for DMT to be orally active, you have to inhibit monoamino oxidases. Although I haven’t seen any models on how 4-subituted tryptamines break down in the body and which enzymes are responsible for that, I think a while back I read an article on Nichols’ work on psilocybin analogs that suggests that 4-aco-DMT is active in its own right. You should search pubmed.

Also consider what side effects you might create by working with enzyme inhibitors and if this is  a worthwhile risk. Part of the reason MAOI anti-depressants never took hold is there are many contraindications.You would want to look at what biologic function deacetylase inhibitors have and what side effects there are in the body. 


I have some 4-aco-MET and 4-ho-MET so I might try to design some double blind studies to see if I can map the differences between those two. My own informal  bioassays suggest that there is a diff between 4-aco-MET  and 4-ho-MET, with the acetoxy being more empathogenic and the hydroxy having more introspective subjective effects.  I’m working on standardizing my research results more.

— 6 days ago with 3 notes
#4acodmt  #serotonin  #5ht  #4hodmt  #david e nichols  #psychedelics  #biochemistry  #neuroscience 
5 canadian dollars, 3 grams of mxe, 1 gram of 4-ho-met, 500mg 4-aco-met, 1 gram of DPT, 1 cuban cigar, and a docu about Pope John Paul II. Kickin it at a loverz haussss

5 canadian dollars, 3 grams of mxe, 1 gram of 4-ho-met, 500mg 4-aco-met, 1 gram of DPT, 1 cuban cigar, and a docu about Pope John Paul II. Kickin it at a loverz haussss

— 1 week ago with 13 notes
#Canada  #Methoxetamine  #4homet  #4acoMET  #DPT  #cuban cigars  #Pope John Paul II  #Catholicism  #gay sex 
fatwalrusbeard asked: I've been doing a bit of 3-MeO-PCP lately because I can't find MXE, but fuck this shit is potent.


Answer:

Indeed it is. It’s not as friendly as MXE if you use too often.

Please, use it with caution. Too much can make you manic.

— 1 week ago with 1 note
fatwalrusbeard asked: Where do you find your RCs? My vendor just got jailed, please help


Answer:

Gurl, if you follow my blog you should know that I don’t source. Sorry to be lame.

— 2 weeks ago with 2 notes
fatwalrusbeard asked: I miss you buddy


Answer:

<3

— 3 weeks ago with 1 note
onewiththediscord asked: what would you say is closest in effects to 4-aco-dmt? I've been researching and 4-ho-met looks similar


Answer:

Psilocybin Mushrooms.

— 3 weeks ago with 2 notes
Anonymous asked: Do you know how a 17 year old can get modafinil


Answer:

Get digital savvy, meng. 0_o_0

— 3 weeks ago