This sounds like a good idea if your proposed mechanism of action is correct. Keep in mind: for DMT to be orally active, you have to inhibit monoamino oxidases. Although I haven’t seen any models on how 4-subituted tryptamines break down in the body and which enzymes are responsible for that, I think a while back I read an article on Nichols’ work on psilocybin analogs that suggests that 4-aco-DMT is active in its own right. You should search pubmed.
Also consider what side effects you might create by working with enzyme inhibitors and if this is a worthwhile risk. Part of the reason MAOI anti-depressants never took hold is there are many contraindications.You would want to look at what biologic function deacetylase inhibitors have and what side effects there are in the body.
#david e nichols
I have some 4-aco-MET and 4-ho-MET so I might try to design some double blind studies to see if I can map the differences between those two. My own informal bioassays suggest that there is a diff between 4-aco-MET and 4-ho-MET, with the acetoxy being more empathogenic and the hydroxy having more introspective subjective effects. I’m working on standardizing my research results more.
Indeed it is. It’s not as friendly as MXE if you use too often.
Please, use it with caution. Too much can make you manic.
Gurl, if you follow my blog you should know that I don’t source. Sorry to be lame.
Get digital savvy, meng. 0_o_0